Peter Diamandis

Rank 13 of 47
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Score 120
1/21/2025, 5:58:52 AM
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In reply to:
David Sinclair
@davidasinclair
·
10h
I hope you found this useful 🙏
David Sinclair
@davidasinclair
·
10h
In summary, more clinical trials are needed to know if the beneficial effects in animals will be seen in humans
David Sinclair
@davidasinclair
·
10h
In 2024, spermidine at 40 mg/day had minimal effects on circulating spermidine in older men & with no significant changes in lipids or blood biomarkers compared to placebo, though the trial was only 28 days
https://www.sciencedirect.com/sc…
David Sinclair
@davidasinclair
·
10h
A RCT in 2023 found longer-term spermidine supplementation in subjects with subjective cognitive decline did not modify memory and biomarkers compared with placebo https://pubmed.ncbi.nlm.nih.gov/…
David Sinclair
@davidasinclair
·
10h
A 2022 RCT with 100 older adults found spermidine supplementation for a year did not alter mnemonic discrimination, as compared with placebo, the ability to differentiate between two memories that are similar https://jamanetwork.com/journals…
David Sinclair
@davidasinclair
·
10h
A 3-month randomized, placebo-controlled, double-blind Phase II trial was conducted with 1.2 mg/day. Spermidine supplementation was apparently safe and well-tolerated in older adults with cognitive decline

The statement is a polite and appreciative response to a detailed discussion on scientific research. It acknowledges the usefulness of the information shared by David Sinclair, who is discussing clinical trials related to spermidine supplementation. The tone is positive and supportive, indicating gratitude for the insights provided.

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